Category	Optimized For	Sensitivity/Specificity	PubMed Equivalent
Therapy	specificity	93%/97%	(randomized controlled trial[Publication Type] OR (randomized[Title/Abstract] AND controlled[Title/Abstract] AND trial[Title/Abstract])) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])
Diagnosis	specificity	64%/98%	(specificity[Title/Abstract]) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])
Etiology	specificity	51%/95%	((relative[Title/Abstract] AND risk*[Title/Abstract]) OR (relative risk[Text Word]) OR risks[Text Word] OR cohort studies[MeSH:noexp] OR (cohort[Title/Abstract] AND stud*[Title/Abstract])) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])
Prognosis	specificity	52%/94%	(prognos*[Title/Abstract] OR (first[Title/Abstract] AND episode[Title/Abstract]) OR cohort[Title/Abstract]) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])
Clinical Prediction Guide	specificity	54%/99%	(validation[tiab] OR validate[tiab]) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])
Systematic Review	balanced specificity and sensitivity	98%/91%	AND (meta analysis[Publication Type] OR meta analysis[Title/Abstract] OR meta analysis[MeSH Terms] OR review[Publication Type] OR search*[Title/Abstract]) NOT (animals[MeSH Terms:noexp]) AND (hasabstract[text]) AND English[Lang] AND ("last 5 years"[PDat])